Back to Course

Clostridioides difficile Infections in Adults by Sarah Kessler, PharmD, BCPS, BCGP

0% Complete
0/0 Steps


Bezlotoxumab Dosing and PK

Bezlotoxumab (Zinplava)

  • Recommended for:
    • Recurrent CDI episode – CDI within the past 6 months
    • Primary CDI with risk factors for recurrence:
      • ≥ 65 years old
      • Immunocompromised
      • Severe CDI on presentation
  • Caution in heart failure
  • Need to take logistics into account
  • Wilcox MH, et al.
    • Patients receiving antibiotic treatment for primary or recurrent CDI had lower rates of recurrent infection than placebo
  • Gerding DN, et al.
    • Patients with 3 or more risk factors had the greatest reduction of recurrent CDI