Patients may require antibiotics during or shortly after completion of CDI therapy
Concern regarding recurrence with ending CDI treatment but continuing other antibiotics
No prospective, RCTs
Guideline Recommendations:
Administer lower doses of standard of care antibiotics
Vancomycin 125mg daily
Fidaxomicin 200mg daily
IF prevention agent is warranted while systemic antibiotics are administered
Prophylaxis Candidates
Considerations for Secondary Prophylaxis:
Length of time from completion of CDI treatment
Patient characteristics:
Number of previous CDI episodes
Severity of presentation
Patient frailty
Prophylaxis
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