Lesson 2 of 2
In Progress

Rabbit Hole: Anaphylaxis

Jimmy September 5, 2021


●     Marcus S. Shaker, Dana V. Wallace, David B.K. Golden, John Oppenheimer, Jonathan A. Bernstein, Ronna L. Campbell, Chitra Dinakar, Anne Ellis, Matthew Greenhawt, David A. Khan, David M. Lang, Eddy S. Lang, Jay A. Lieberman, Jay Portnoy, Matthew A. Rank, David R. Stukus, Julie Wang, Natalie Riblet, Aiyana M.P. Bobrownicki, Teresa Bontrager, Jarrod Dusin, Jennifer Foley, Becky Frederick, Eyitemi Fregene, Sage Hellerstedt, Ferdaus Hassan, Kori Hess, Caroline Horner, Kelly Huntington, Poojita Kasireddy, David Keeler, Bertha Kim, Phil Lieberman, Erin Lindhorst, Fiona McEnany, Jennifer Milbank, Helen Murphy, Oriana Pando, Ami K. Patel, Nicole Ratliff, Robert Rhodes, Kim Robertson, Hope Scott, Audrey Snell, Rhonda Sullivan, Varahi Trivedi, Azadeh Wickham, Marcus S. Shaker, Dana V. Wallace, Marcus S. Shaker, Dana V. Wallace, Jonathan A. Bernstein, Ronna L. Campbell, Chitra Dinakar, Anne Ellis, David B.K. Golden, Matthew Greenhawt, Jay A. Lieberman, Matthew A. Rank, David R. Stukus, Julie Wang, Marcus S. Shaker, Dana V. Wallace, David B.K. Golden, Jonathan A. Bernstein, Chitra Dinakar, Anne Ellis, Matthew Greenhawt, Caroline Horner, David A. Khan, Jay A. Lieberman, John Oppenheimer, Matthew A. Rank, Marcus S. Shaker, David R. Stukus, Julie Wang,
Anaphylaxis—a 2020 practice parameter update, systematic review, and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) analysis,Journal of Allergy and Clinical Immunology,
Volume 145, Issue 4,2020,Pages 1082-1123,ISSN 0091-6749,https://doi.org/10.1016/j.jaci.2020.01.017.

●     Matthew Greenhawt, Ruchi S. Gupta, J. Allen Meadows, Michael Pistiner, Jonathan M. Spergel, Carlos A. Camargo, F. Estelle R. Simons, Philip L. Lieberman,
Guiding Principles for the Recognition, Diagnosis, and Management of Infants with Anaphylaxis: An Expert Panel Consensus,The Journal of Allergy and Clinical Immunology: In Practice,
Volume 7, Issue 4,2019,Pages 1148-1156.e5,ISSN 2213-2198,https://doi.org/10.1016/j.jaip.2018.10.052.

●     American Academy of Pediatrics. Treatment of Anaphylactic Reactions. In: eds. Red Book: 2021–2024 Report of the Committee on Infectious Diseases. American Academy of Pediatrics; 2021; 64-67

●    Simons, F.E.R., Ardusso, L.R.F., Bilò, M.B. et al. World Allergy Organization Guidelines for the Assessment and Management of Anaphylaxis. World Allergy Organ J 4, 13–37 (2011). https://doi.org/10.1097/WOX.0b013e318211496c

●    Simons, F. Estelle R.; Ardusso, Ledit R.F.; Bilò, M. Beatrice; Dimov, Vesselin; Ebisawa, Motohiro; El-Gamal, Yehia M.; Ledford, Dennis K.; Lockey, Richard F.; Ring, Johannes; Sanchez-Borges, Mario; Senna, Gian Enrico; Sheikh, Aziz; Thong, Bernard Y.; Worm, Margitta for the World Allergy Organization 2012 Update, Current Opinion in Allergy and Clinical Immunology: August 2012 – Volume 12 – Issue 4 – p 389-399 doi: 10.1097/ACI.0b013e328355b7e4

●    Simons, F.E.R., Ebisawa, M., Sanchez-Borges, M. et al. 2015 update of the evidence base: World Allergy Organization anaphylaxis guidelines. World Allergy Organ J 8, 1–16 (2015). https://doi.org/10.1186/s40413-015-0080-1

Primary Literature

●     Kim TH, Yoon SH, Hong H, Kang HR, Cho SH, Lee SY. Duration of Observation for Detecting a Biphasic Reaction in Anaphylaxis: A Meta-Analysis. Int Arch Allergy Immunol. 2019;179(1):31-36. doi: 10.1159/000496092. Epub 2019 Feb 14. PMID: 30763927.

●    Grabenhenrich LB, Dölle S, Ruëff F, Renaudin JM, Scherer K, Pföhler C, Treudler R, Koehli A, Mahler V, Spindler T, Lange L, Bilò MB, Papadopoulos NG, Hourihane JOB, Lang R, Fernández-Rivas M, Christoff G, Cichocka-Jarosz E, Worm M. Epinephrine in Severe Allergic Reactions: The European Anaphylaxis Register. J Allergy Clin Immunol Pract. 2018 Nov-Dec;6(6):1898-1906.e1. doi: 10.1016/j.jaip.2018.02.026. Epub 2018 Mar 30. PMID: 29606638.

●    Sicherer SH, Simons FER; SECTION ON ALLERGY AND IMMUNOLOGY. Epinephrine for First-aid Management of Anaphylaxis. Pediatrics. 2017 Mar;139(3):e20164006. doi: 10.1542/peds.2016-4006. Epub 2017 Feb 13. PMID: 28193791.

●    Kawano T, Scheuermeyer FX, Gibo K, Stenstrom R, Rowe B, Grafstein E, Grunau B. H1-antihistamines Reduce Progression to Anaphylaxis Among Emergency Department Patients With Allergic Reactions. Acad Emerg Med. 2017 Jun;24(6):733-741. doi: 10.1111/acem.

●    Lee SH, Park HW, Cho SH, Kim SS. The efficacy of single premedication with antihistamines for radiocontrast media hypersensitivity. Asia Pac Allergy. 2016 Jul;6(3):164-7. doi: 10.5415/apallergy.2016.6.3.164. Epub 2016 Jul 28. PMID: 27489788; PMCID: P

●    Grunau BE, Wiens MO, Rowe BH, McKay R, Li J, Yi TW, Stenstrom R, Schellenberg RR, Grafstein E, Scheuermeyer FX. Emergency Department Corticosteroid Use for Allergy or Anaphylaxis Is Not Associated With Decreased Relapses. Ann Emerg Med. 2015 Oct;66(4

●    Ko BS, Kim WY, Ryoo SM, Ahn S, Sohn CH, Seo DW, Lee YS, Lim KS, Kim TB. Biphasic reactions in patients with anaphylaxis treated with corticosteroids. Ann Allergy Asthma Immunol. 2015 Oct;115(4):312-6. doi: 10.1016/j.anai.2015.07.015. Epub 2015 Aug 12

●    Michelson KA, Monuteaux MC, Neuman MI. Glucocorticoids and Hospital Length of Stay for Children with Anaphylaxis: A Retrospective Study. J Pediatr. 2015 Sep;167(3):719-24.e1-3. doi: 10.1016/j.jpeds.2015.05.033. Epub 2015 Jun 19. PMID: 26095285.

●    Campbell RL, Bellolio MF, Knutson BD, Bellamkonda VR, Fedko MG, Nestler DM, Hess EP. Epinephrine in anaphylaxis: higher risk of cardiovascular complications and overdose after administration of intravenous bolus epinephrine compared with intramuscula

●    Banerji A, Rudders S, Clark S, Wei W, Long AA, Camargo CA Jr. Retrospective study of drug-induced anaphylaxis treated in the emergency department or hospital: patient characteristics, management, and 1-year follow-up. J Allergy Clin Immunol Pract. 20

●    Kolbe AB, Hartman RP, Hoskin TL, Carter RE, Maddox DE, Hunt CH, Hesley GK. Premedication of patients for prior urticarial reaction to iodinated contrast medium. Abdom Imaging. 2014 Apr;39(2):432-7. doi: 10.1007/s00261-013-0058-9. PMID: 24389892.

●    Manivannan V, Hess EP, Bellamkonda VR, Nestler DM, Bellolio MF, Hagan JB, Sunga KL, Decker WW, Li JT, Scanlan-Hanson LN, Vukov SC, Campbell RL. A multifaceted intervention for patients with anaphylaxis increases epinephrine use in adult emergency dep

●    Simons FE, Gu X, Silver NA, Simons KJ. EpiPen Jr versus EpiPen in young children weighing 15 to 30 kg at risk for anaphylaxis. J Allergy Clin Immunol. 2002 Jan;109(1):171-5. doi: 10.1067/mai.2002.120758. PMID: 11799385.

●    Simons FE, Gu X, Simons KJ. Epinephrine absorption in adults: intramuscular versus subcutaneous injection. J Allergy Clin Immunol. 2001 Nov;108(5):871-3. doi: 10.1067/mai.2001.119409. PMID: 11692118.

●    Lin RY, Curry A, Pesola GR, Knight RJ, Lee HS, Bakalchuk L, Tenenbaum C, Westfal RE. Improved outcomes in patients with acute allergic syndromes who are treated with combined H1 and H2 antagonists. Ann Emerg Med. 2000 Nov;36(5):462-8. doi: 10.1067/me

●    Lasser EC, Berry CC, Mishkin MM, Williamson B, Zheutlin N, Silverman JM. Pretreatment with corticosteroids to prevent adverse reactions to nonionic contrast media. AJR Am J Roentgenol. 1994 Mar;162(3):523-6. doi: 10.2214/ajr.162.3.8109489. PMID: 8109

Review Articles

●    American College of Radiolgy Manual on Contrast Media

●    Park SJ, Kang DY, Sohn KH, Yoon SH, Lee W, Choi YH, Cho SH, Kang HR. Immediate Mild Reactions to CT with Iodinated Contrast Media: Strategy of Contrast Media Readministration without Corticosteroids. Radiology. 2018 Sep;288(3):710-716. doi: 10.1148/r

●    Prince BT, Mikhail I, Stukus DR. Underuse of epinephrine for the treatment of anaphylaxis: missed opportunities. J Asthma Allergy. 2018 Jun 20;11:143-151. doi: 10.2147/JAA.S159400. PMID: 29950873; PMCID: PMC6016581.

●    Pourmand A, Robinson C, Syed W, Mazer-Amirshahi M. Biphasic anaphylaxis: A review of the literature and implications for emergency management. Am J Emerg Med. 2018 Aug;36(8):1480-1485. doi: 10.1016/j.ajem.2018.05.009. Epub 2018 May 9. PMID: 29759531.

●    Alqurashi W, Ellis AK. Do Corticosteroids Prevent Biphasic Anaphylaxis? J Allergy Clin Immunol Pract. 2017 Sep-Oct;5(5):1194-1205. doi: 10.1016/j.jaip.2017.05.022. PMID: 28888249.

●    Mostmans Y, Grosber M, Blykers M, Mols P, Naeije N, Gutermuth J. Adrenaline in anaphylaxis treatment and self-administration: experience from an inner city emergency department. Allergy. 2017 Mar;72(3):492-497. doi: 10.1111/all.13060. Epub 2016 Nov 1

●    Davenport MS, Cohan RH. The Evidence for and Against Corticosteroid Prophylaxis in At-Risk Patients. Radiol Clin North Am. 2017 Mar;55(2):413-421. doi: 10.1016/j.rcl.2016.10.012. PMID: 28126223.

●    Liyanage CK, Galappatthy P, Seneviratne SL. Corticosteroids in management of anaphylaxis; a systematic review of evidence. Eur Ann Allergy Clin Immunol. 2017 Sep;49(5):196-207. doi: 10.23822/EurAnnACI.1764-1489.15. PMID: 28884986.

●    Nurmatov UB, Rhatigan E, Simons FE, Sheikh A. H2-antihistamines for the treatment of anaphylaxis with and without shock: a systematic review. Ann Allergy Asthma Immunol. 2014 Feb;112(2):126-31. doi: 10.1016/j.anai.2013.11.010. Epub 2013 Dec 5. PMID: 

●    Simons KJ, Simons FE. Epinephrine and its use in anaphylaxis: current issues. Curr Opin Allergy Clin Immunol. 2010 Aug;10(4):354-61. doi: 10.1097/ACI.0b013e32833bc670. PMID: 20543673.

●    Moneret-Vautrin DA, Morisset M, Flabbee J, Beaudouin E, Kanny G. Epidemiology of life-threatening and lethal anaphylaxis: a review. Allergy. 2005 Apr;60(4):443-51. doi: 10.1111/j.1398-9995.2005.00785.x. PMID: 15727574.

●    Croxtall JD, Choudhury Q, Flower RJ. Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism. Br J Pharmacol. 2000 May;130(2):289-98.

●    Kaliner M, Sigler R, Summers R, Shelhamer JH. Effects of infused histamine: analysis of the effects of H-1 and H-2 histamine receptor antagonists on cardiovascular and pulmonary responses. J Allergy Clin Immunol. 1981 Nov;68(5):365-71. doi: 10.1016/0

Podcasts & Medical Blogs

●    https://emcrit.org/ibcc/anaphylaxis/

●    https://emcrit.org/pulmcrit/anaphylaxis/

●    https://emcrit.org/pulmcrit/iv-epinephrine-anaphylaxis/

●    https://emcrit.org/emcrit/iv-bolus-epinephrine-for-anaphylaxis/

●    https://emcrit.org/pulmcrit/test-dose/

●    https://rebelem.com/may-2015-rebelcast/

●    https://rebelem.com/rebelcast-episode-1/

●    https://www.theresusroom.co.uk/courses/anaphylaxis/

●    https://edecmo.org/edecmo-31-anaphylaxis-epi-pens-ready-vv-ecmo-emergency-department/

●    https://litfl.com/anaphylaxis/

●    https://litfl.com/pediatric-anaphylaxis/

●    https://litfl.com/anaphylaxis-ddx/

●    https://litfl.com/top-10-pearls-for-managing-anaphylaxis/

●    https://litfl.com/biphasic-anaphylaxis-after-using-autoinjector-now-what/