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Pharmacy & Acute Care University
Pharmacy & Acute Care University
Lesson 1 of 0
In Progress

Rationale and Mechanism of Action of Epinephrine

Jimmy September 14, 2021

Vasopressor Activity Chart

Epinephrine Pros

  • Alpha1
    • Arterial vasoconstriction
    • Venous vasoconstriction
    • Coronary vasoconstriction
  • Alpha2
    • Venous vasoconstriction
  • ↑ SVR = ↑ CPP + ↑ oxygen delivery

Epinephrine Cons

  • Alpha1
    •  ↑ Cerebral constriction
  • Beta1 + Beta2
    • ↑ Inotropy
    • ↑ Oxygen demand
    • ↑ Recurrent VF
    • ↑ Clotting

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